In addition to HLA-G, HLA-E expression can be observed in multiple cancer entities such as breast cancer [132], colorectal cancer [158,159,160,201], renal cancer [173,202,203], lung cancer [204], melanoma [205,206], and gastric cancer [207,208], cervical cancer (adenocarcinoma) [209], glioblastoma [174,177,210], Hepatic carcinoma (hepatocellular) [211], Hodgkin’s lymphoma [212], Thyroid cancer [213] and leukemia [214]. This evidence concerns the gene HLA-G and melanoma.