For example, Garvin et al. found that 100 μM RSV induced significant morphological changes indicative of apoptosis in MDA-MB-231 breast cancer cells [30], and Wong et al. also found that 100 μM RSV promoted apoptosis by mediating caspase-3/7 activation and induced morphologic changes in cultured ovarian theca-interstitial (T-I) cells [22], these findings both based on the same concentration utilized in our study. This evidence concerns the gene CASP3 and breast cancer.