BCL2 and uterine corpus leiomyoma: According to previous studies, the anti-apoptotic mechanism seems to be involved in the development of uterine leiomyoma; several studies have demonstrated that the anti-apoptotic Bcl-2 gene was significantly over-expressed in uterine leiomyoma compared to homologous myometrium [40], and can even be influenced by the endocrine environment [41].