As shown in Figure 4C, leiomyoma cells exposed to 100 μM RSV showed a significantly lower mRNA expression of FN1. In addition, Western blot analysis showed that 100 μM RSV significantly decreased the levels of COL1A1, α-SMA, and β-catenin compared to controls for 48 h (Figure 4D,F,G). This evidence concerns the gene COL1A1 and leiomyoma.