ARHGAP5 and colorectal adenoma: However, a genome-wide investigation into copy number variations of 221 colorectal adenomatous polyposis samples revealed recurrent alterations in three genes from the ARHGAP family, among which was ARHGAP5. A partial duplication and several somatic point mutations in this latter gene suggest a role for p190B in colorectal adenoma formation, and classify ARHGAP5 as a candidate gene that may increase the risk of hereditary colorectal tumors [87].