Even if few hotspots may be distinguished (i.e., R997* in endometrial tumors [82] or E1273A in thyroid tumors or renal angiomyolipoma [85,86]), ARHGAP35 mutations are observed all along the gene with nonsense mutations and frameshift deletions/insertions supporting a tumor-suppressor role for p190A (tumorportal website (http://www.tumorportal.org/)). Here, ARHGAP35 is linked to kidney angiomyolipoma.