RASSF1 and neoplasm: Also, we found significant promoter hypermethylation in high tumor grades of OC for p16INK4a and RASSF1A and of OPC for p16INK4a, RASSF1A, and TIMP3, suggesting the correlation between promoter hypermethylation of tumor-related genes and poor prognosis of OC and OPC [26,61,62].