DNMT3A and acute myeloid leukemia: Mechanically, DNMT3A-R882H directly binds to the HOXA gene cluster, therefore inducing DNA hypomethylation as well as H3K27 acetylation and promoting transcriptional activation of Meis1, Mn1, and HOXA that are required for DNMT3A-R882H-mediated AML progression [87].