Once the H3K27me3 epigenetic signature was lost at HOXA clusters, HOXA gene expression significantly increased, in particular for HOXA9 and HOXA10. Mechanistically, ASXL1 loss-of-function mutations upregulates the expression level of HOXA genes by altering their methylation profile, leading to the development of cancer [88]. Here, HOXA10 is linked to cancer.