Deletion of the risk region harboring several prostate cancer risk-associated SNPs using CRISPR (clustered regularly interspaced palindromic repeats)-Cas (CRISPR-associated proteins)-mediated genome editing resulted in a loss of one anchor point of the repressive chromatin loop, which may subsequently alter the three-dimensional chromatin structure and cause upregulation of HOXA13 and HOTTIP in the HOXA locus, leading to genome-wide transcriptomic changes [53]. Here, HOXA13 is linked to Familial prostate cancer.