As shown in (Figure 3A), 24 h after transfection of BT-474, SKBR3, and HCC-1419 cells with scrambled PSMD3-Si001 or PSMD3-Si002 plasmids, the total HER2 (185 kDa) in siRNA-transfected cells was significantly reduced compared to un-transfected cells or cells transfected with the scrambled siRNA. The gene discussed is PSMD3; the disease is hepatocellular carcinoma.