TRPML-1 has been also found to target the Apoptosis-linked gene-2 (ALG-2), also known as programmed cell death 6 (PDCD6), which codifies for ALG-2, an EF-hand-containing protein promoting caspase-3-independent-cell death, associated to GBM progression and poor prognosis [17,18]. The gene discussed is PDCD6; the disease is glioblastoma.