The levels of BNP are significantly high in Takotsubo cardiomyopathy, and early BNP/cTnT and BNP/CK-MB ratios help differentiate Takotsubo cardiomyopathy from acute myocardial infarction (AMI) with greater accuracy than BNP alone [75]. This evidence concerns the gene NPPB and acute myocardial infarction.