Studies in postmortem individuals have demonstrated that BNP and NT-proBNP concentrations were significantly elevated in the blood and pericardial fluid of the deceased who died from acute ischemic heart disease (with or without myocardial necrosis), chronic congestive heart disease, arrhythmogenic right ventricular cardiomyopathy, and more. This evidence concerns the gene NPPB and arrhythmogenic right ventricular cardiomyopathy.