In recent years, many forensic studies have demonstrated that BNP and NT-proBNP could be used to reflect the cardiac function of the deceased before their death through extensive animal experiments and postmortem specimens, and they could also be used as postmortem biomarkers for the diagnosis of HF or cardiac dysfunction in forensic medicine [9,10,18,19,20]. The gene discussed is NPPB; the disease is hydrops fetalis.