Wu et al. reported shRNA-mediated knockdown of AQP1 in two osteosarcoma lines U2OS and MG63 resulted in promotion of apoptosis with reduction in the level of antiapoptotic protein BCL-2 and increase in the levels of proapoptotic protein Bax and cleaved caspase 3 [26]. The gene discussed is CASP3; the disease is osteosarcoma.