Treatment of NSCLC cell lines LLC and LTEP-A2 with AQP1 siRNA and the resultant knockdown of the expression have also been reported to reduce transwell migration and invasion as well as wound closure and was accompanied by reduced expression of MMP-2 and metallopeptidase-9 (MMP-9) [33]. This evidence concerns the gene AQP1 and non-small cell lung carcinoma.