Importantly, all the above-mentioned genes were upregulated in R1 cell-derived tumor xenograft with respect to parental cell-derived tumor xenograft (Figure 4B) and some of them (KIT, SERPINE, TWIST1, TWIST2, and ZEB2) could even be included in the top upregulated gene list of R1 cell-derived tumor xenograft versus parental cell-derived tumor xenograft (Figure 4C). The gene discussed is TWIST1; the disease is neoplasm.