While ESCO2 was also upregulated in R2 cells (although 2.5-fold less than in R1 cells), R2 cells highly downregulated the chromatin remodeling genes HDAC4 and DOT1L. HDAC4 promotes growth of colon cancer cells via repression of p21 [66]. The gene discussed is CDKN1A; the disease is colonic neoplasm.