Some studies indicated the role of USF2 as a tumor suppressor in prostate cancer [21], breast cancer [22,23] and oral cancer [24], whereas other studies suggested a role as a tumor-promoter in small cell lung cancer and squamous cell carcinoma [25], hepatocellular carcinoma (HCC) cell lines and in patients with liver cirrhosis [26] as well as in breast cancer [27]. The gene discussed is USF2; the disease is breast cancer.