Indeed, it has been shown that USF2 is a phosphoprotein [28,29] and that a number of tumor entities such as prostate cancer [30,31,32,33], hepatocellular carcinoma [34,35,36,37] and breast cancer [38,39,40] are associated with an aberrant USF2 function (for review see [13]). Here, USF2 is linked to hepatocellular carcinoma.