By measuring the proliferation rate (Figure 5A,B), BrdU incorporation (Figure 5C,D), apoptosis (Figure 5E,F) and migration (Figure 5G,H) of ΔCDK5 PC3, ΔCDK5 HepG2 and ΔCDK5 MBA-MD-231 cells in comparison to the respective control Sc cells, we found that absence of CDK5 reduced the proliferation and migration of PC3, HepG2, and MDA-MB-231 cancer cell lines in line with previous reports [33,37,38] and did not affect apoptosis (Figure 5E,F). This evidence concerns the gene CDK5 and cancer.