CD44 and cancer: Varying doses and duration of administration of CUR on cancer stem cells using a wide array of cell cultures models (breast, colon, and lung cancer) showed antitumor activity, with a reduction in the formation of new spheres, activation of caspases, and other pro-apoptotic proteins, as well as downregulation of markers for stemness (CD133, CD44, ALDH1 [aldehyde dehydrogenasis]), increased availability, and activation of PARP (poly[ADP-ribose]-polymerase) inducing sensitivity to anti-cancer drugs like 5-fluoruracil and dasatinib in colon cancer cells, and cisplatinum in lung cancer cells [35].