In addition to its role as a cofactor for GGCX, vitamin K is involved in the transcriptional regulation of the nuclear receptor the steroid and xenobiotic sensing nuclear receptor (SXR) (also known as pregnane X receptor or PXR) [3,4,5] and regulates protein kinase A (PKA) signaling in osteoblasts and hepatocellular carcinoma cells [6]. Here, NR1I2 is linked to hepatocellular carcinoma.