A-glucosylhesperidin is extracted from citrus fruits, and exerts anti-RA effects via downregulation of tumor necrosis factor α (TNFα) at a dose of 3 mg per 0.3 mL when it was administered on a collagen-induced arthritis (CIA) rat model 3 times a week for 31 days [27]. This evidence concerns the gene TNF and rheumatoid arthritis.