Hydroxytyrosol acetate (Hty-Ac), also from EVOO, showed anti-RA effects by inhibiting IgG1, IgG2a, COMP, MMP-3, TNF-Q, IFN-S, IL-1R, IL-6, IL-17A, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), and heme oxygenase 1 (HO-1) at a dose of 0.5% when CIA rats were treated for 42 days [50]. The gene discussed is HMOX1; the disease is rheumatoid arthritis.