MMP2 and rheumatoid arthritis: Epigallocatechin-3-gallate (EGCG), a well-known compound from Camellia sinensis, exerted anti-RA effects on human rheumatoid arthritis synovial fibroblasts (RASF) by downregulating epithelial neutrophil-activating peptide (ENA)-78, RANTES, growth-regulated oncogene (GRO)-α, IL-1–induced MMP-2, chemokine-induced MMP-2 at doses of 10, 20, 30, 40 and 50 μM when administered for 12 h [30].