Also, RF positivity, SJC-28, TJC-28, CRP, erythrocyte sedimentation rate (ESR), uncarboxylated osteocalcin (ucOC), MMP-3, TNF-α, IL-6, disease Activity Score-28 for Rheumatoid Arthritis with ESR (DAS28-ESR) levels were alleviated [21]. This evidence concerns the gene IL6 and rheumatoid arthritis.