Curcumin, from rhizome of Curcuma longa, likewise demonstrated anti-RA effects via suppression of Bcl-2, caspase-3, caspase-9, ADP-ribose, and COX-2 of FLS when human FLS were treated for 24 h with a dose of 25, 50, 75, and 100 μM [53]. This evidence concerns the gene BCL2 and rheumatoid arthritis.