TNFSF10 and neoplasm: Several intracellular signaling molecules, including cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP), inhibitor of apoptosis proteins, p38 mitogen-activated protein kinase (p38 MAPK), and nuclear factor (NF)-κB, have been implicated in the regulation of TRAIL resistance in tumor cells [11,12,13,14,15].