Considering the role played by HuD upregulation in nerve regeneration upon lesion [21], a possible scenario in diabetes would be: (i) hyperalgesia (early phases of diabetes) is associated with HuD upregulation involved in nerve regeneration, (ii) hypoalgesia (late phases of diabetes) is associated with HuD downregulation, when its ability to regulate mRNA proteins involved in nerve recovery is overcome. This evidence concerns the gene ELAVL4 and diabetes mellitus.