RYR2 and neuropathy: HuD is upregulated and contributes to pain hypersensitivity to mechanical and cold stimulation in antiretroviral-evoked painful neuropathy by regulating spinal ryanodine receptor-2 [50] or GAP43 [19,51] or contributes to thermal hot hyperalgesia in oxaliplatin-induced neuropathy by regulating GAP43 [52].