Moreover, the expression of CDH1 (E-cadherin) decreased, and the expression of CDH2 (N-cadherin) and VIM (vimentin) increased in the dECM compared to 2D culture with plastic dishes and culture on Matrigel, which is a crude extract of the basement membrane formed by Engelbreth-Holm-Swarm sarcomas. Here, CDH1 is linked to sarcoma.