FGF1 and neoplasm: Platelets induce tumor angiogenesis by secreting proangiogenetic cytokines such as vascular endothelial growth factor (VEGF), PDGF, transforming growth factor (TGF), endothelial cell growth factor (ECGF), insulin-like growth factor (ILGF), basic fibroblast growth factor (bFGF, FGF-2), angiopoietin-1 as well as the lipid mediator sphingosine-1-phosphate [33].