The level of NFTs and tau modifications are correlated to the severity of the tauopathies, including Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD), FTD with parkinsonism linked to chromosome-17 (FTDP-17), frontotemporal lobar degeneration (FTLD), Pick’s disease (PiD), progressive supranuclear palsy (PSP), corticobasal neurodegeneration (CBD), dementia pugilistica, etc. [9,10,11,12]. Here, MAPT is linked to Alzheimer disease.