Other potential mouse models of PTCL for pre-clinical testing are deficient in Tet2, either with the RhoaG17V [40] or without the mutation [41], or bear a translocation between ITK and spleen tyrosine kinase (SYK), a chromosomal abnormality, which is found in a small minority of AITL [42]. Here, ITK is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.