When the cells were treated with LF +PA or EF +PA, the Lep-vesicle-recycling endosome-exocyst complexes were absent during infection (Figure 4G and Figure 4—figure supplement 1C ), while the treatment of anthrax toxins did not affect leptospiral uptake into the cells compared with untreated cells (Figure 4H and Figure 4—figure supplement 1D ). The gene discussed is LEP; the disease is infection.