MAVS and infection: The infection of miRNA-transfected Dgcr8-/- cells with TMEV resulted in an increase in both susceptibility and viral replication for miR-125a-5p, miR-125b-5p and miR-673–5p, which correlated with the ability of these miRNAs to downregulate MAVS protein levels (Figure 5B and Figure 5—figure supplement 1B).