There was a large increased risk of severe hypoglycemia associated with CYP2C9 decreased and nonfunctional variants but only in the presence of normal function POR (*1*1) (OR 2.81 (1.30–6.09), P = 0.009 per number of CYP2C9 decreased‐function alleles). This evidence concerns the gene CYP2C9 and Hypoglycemia.