To investigate the relationship between TRERNA1 and SNAI1 in the process of HCC migration, HepG2 cells were transfected with SNAI1, SNAI1 + TRERNA1, SNAI1 + siTRERNA1 or control (ctrl), and HepG2.215 cells were treated with siSNAI1, siSNAI1 + siTRERNA1, siSNAI1 + TRERNA1 or control (ctrl). This evidence concerns the gene TRERNA1 and hepatocellular carcinoma.