In our previous study, we firstly explored circRNA has_circ_0043256 function and its involvement in the mechanism of cinnamaldehyde against lung adenocarcinoma through its action as an endogenous sponge of miR‐1252, releasing its target ITCH, and regulating Wnt/β‐catenin pathway.20 Thus, circRNAs were identified as important regulatory RNAs in lung cancer rather than by‐products of mRNA spliced. Here, ITCH is linked to lung adenocarcinoma.