EPCAM and neoplasm: Because identification of EpCAM on normal tissues by high-affinity anti-EpCAM mAbs (KD of 1 nM) leads to severe adverse events, such as acute pancreatitis in patients, the moderate affinity of MT110 for EpCAM (ranging from 10 to 100 nM) enables it to discriminate EpCAM-overexpressing tumor cells from normal epithelial cells with low levels of accessible EpCAM.16