To couple the activation signals, such as BCR signaling pathway, involved in autoimmune diseases, with the inhibition one, a DART molecule consisting of humanized variable domains specifically recognizing CD32B and CD79B (CD79B is the Igβ in the signal-transducing part of the BCR complex) was designed by Veri et al.109, 110 The CD32B×CD79B DART benefits from the two particular characteristics; the first is its CD32B-specific variable domains that show superior affinities for their target compared with the CD79B-specific variable domains, favoring CD32B recognition. The gene discussed is BCR; the disease is autoimmune disease.