POU5F1B and cancer: The dysregulation of pseudogenes has a close connection with human disorders, especially cancer.18, 19, 20, 21 Several cancer-associated pseudogenes have been identified, including PTENP1,22 HMGA1P6, HMGA1P7,23 POU5F1B,24 FOXO3P,25 and INTS6P1.26