TLR4 and atherosclerosis: For example, it is shown that in vascular smooth muscle cells, fenofibrate as an agonist of PPARα showed anti-inflammatory activity in which it can regulate the inflammation response triggered by angiotensin II through disturbing the TLR-4 related signaling pathways (TLR-4/IP-10/PKC/NF-κB), a hindrance against atherosclerosis.26