In the mouse model of sepsis, the treatment with pioglitazone attenuated the production of pro-inflammatory cytokines such as TNF-α and IL-1b while elevated IL-10 levels. This effect of pioglitazone was associated with a decreased expression of MyD88 in in vitro and in vitro. Blocking IL-10 receptor suppresses this effect. The gene discussed is IL10; the disease is Sepsis.