SIRT3 and pulmonary fibrosis: The notable insights related to systemic aging include how: (i) overweight leads to muscle loss and alters mitochondrial metabolism; (ii) an intricate network of many inflammatory mediators converge to cause chronic inflammation; (iii) modulation of miR-34a may promote healthy heart and brain; (iv) enhanced expression of SIRT3 may reduce cardiac and pulmonary fibrosis; and (v) intensive statin therapy can reduce the degree of stenosis in AICAS patients.