Additional articles on systemic aging suggested that age-related loss of brain white matter is linked to chronic systemic inflammation, hypertension is a result of reduced miR-181b-5p transforming VSMCs by increasing HMGB1, cataract formation occurs via deficiency of Yes-associated protein, several miRs and lncRNAs have potential as biomarkers and therapeutic targets for the CAD, higher meat consumption can cause sleep problems, and poorer glycemic control is associated with depression. This evidence concerns the gene HMGB1 and depressive symptom measurement.