A study of 15 acute ischemic stroke patients demonstrated that C5a in the plasma began to increase at 7 days and was maintained at a plateau up to 14 days, while C5b-9 decreased after 1 and 2 days of ischemic stroke and showed no difference up to 28 days after ischemic stroke compared to the healthy control [48]. This evidence concerns the gene C5 and ischemic stroke.