SNCA and Parkinson disease: Tubulin polymerization-promoting protein (TPPP/p25) is enriched in neurological brain lesions and its accumulation may contribute to alpha-synuclein aggregation in PD brains; miR-1 targets TPPP/p25, therefore reductions of miR-1 can lead to pathological overexpression of TPPP/p25 and subsequent alpha-synuclein aggregates [186].