Considering that SNX10 has also been reported to be associated with a diminished production of systemic pro-inflammatory cytokines [27], increasing SNX10 levels could favor macrophage polarization into M2 phenotype, exerting anti-inflammatory action after tissue injury in ALS patients, when the denervation process has started as increasing NOGO A levels suggested, which is in accordance with previous studies [28-32]. Here, SNX10 is linked to amyotrophic lateral sclerosis.