SNX10 levels were found significantly associated with the familial ALS patients’ group (OR: 0.489, CI: 0.268-0.892, P =0.020), with ALS patients with an age at onset higher than 55 years (OR: 0.351, CI: 0.173-0.714, P =0.004), and with patients showing a possible, probable or suspected El Escorial criteria at onset (OR: 0.417, CI: 0.211-0.822, P =0.012). The gene discussed is SNX10; the disease is amyotrophic lateral sclerosis.