Binary logistic regression analysis showed that ALS patients that exhibited ALSFRS-r scores at sampling higher or equal than 40, also showed a probability of expressing lower COL19A1 gene and protein levels than ALS patients with ALSFRS-r scores at sampling lower than 40 (COL19A1 gene levels: odds ratio (OR): 0.839, 95% confidence of interval (CI): 0.714-0.987, P =0.034; COL19A1 protein levels: OR: 0.977, CI: 0.877-1.089, P =0.674). The gene discussed is COL19A1; the disease is amyotrophic lateral sclerosis.