Additionally, the diagnostic delay correlated positively with the disease duration in ALS patients that exhibited low COL19A1 gene levels (B coefficient: 0.909, CI: 0.556-1.263, P <0.0001), suggesting that low COL19A1 gene levels were closely associated with ALS patients that showed a longer disease duration and therefore, a diagnostic delay higher than one year. This evidence concerns the gene COL19A1 and amyotrophic lateral sclerosis.