Albeit COL19A1 levels were found significantly higher in the ALS patient group respect to the healthy and ONP groups, this difference in the gene expression levels was not so remarkable than the difference observed in the muscle biopsy cohort (approximately 1.75-fold change respect to the healthy control group and 2.35-fold change respect to the ONP group), which is in accordance with the fact that COL19A1 gene is mostly expressed and related to the skeletal muscle tissue, rather than blood tissue. The gene discussed is COL19A1; the disease is amyotrophic lateral sclerosis.