Finally and after analyzing the prognostic nature of the genes along the disease progression, Cox proportional hazards regression model suggested that COL19A1 gene levels above average (0.819) and a fast progression of the disease, based on high scores of the ALSFRS-r slope at onset (≥ 1 points/month) could favored a shorter lifespan in ALS patients (ALSFRS-r slope, HR: 5.798, CI: 3.405-9.872, P <0.001; COL19A1 levels, HR: 2.291, CI: 1.435-5.945, P =0.003). This evidence concerns the gene COL19A1 and amyotrophic lateral sclerosis.