This analysis suggested that the lifespan in ALS patients showing COL19A1 protein levels above mean average (1.06) and additionally a fast progression of the disease (ALSFRS-r slope scores at sampling ≥ 1 points/month) could be reduced 70.5% (ALSFRS-r slope, hazard ratio, HR: 1.569, CI: 1.245-1.976, P =0.000; COL19A1 protein levels, HR: 2.158, CI: 1.020-4.566, P =0.044), emphasizing the significance of COL19A1 levels as a useful, feasible, and potentially prognostic factor in patients with ALS. Here, COL19A1 is linked to amyotrophic lateral sclerosis.