Compared with the healthy control group, the level of pepsinogen (256.53 ± 69.53 [spleen deficiency-FD group] vs. 310.00 ± 66.06 [healthy control group], p < 0.01), gastrin (64.91 ± 17.52 vs. 85.82 ± 11.41, p < 0.01), ghrelin (75.58 ± 17.52 vs. 98.67 ± 12.92, p < 0.01), motilin (555.85 ± 128.12 vs. 754.01 ± 113.27, p < 0.01) were significantly reduced and the level of cholecystokinin (688.96 ± 114.35 vs. 647.71 ± 93.64, p < 0.05) was increased in the spleen deficiency group. This evidence concerns the gene CCK and Fabry disease.