CCK and Fabry disease: Recently, evidence has accumulated that delayed gastric emptying rate is closely associated with altered gastrointestinal hormones [22, 23] in the current study, we showed that gastrointestinal hormones (pepsinogen, gastrin, ghrelin, motilin) were significantly reduced, and the cholecystokinin level was increased, in the spleen deficiency-FD group compared with the non-spleen deficiency-FD group and healthy control group.