In recent years, drugs for the treatment of RA have been continuously put into clinical treatment, such as glucocorticoids, tumor necrosis factor-alpha (TNF-α) inhibitors, technetium [99Tc] methylene diphosphonate injection, nonsteroidal anti-inflammatory drugs (NSAIDs), biological targeting agents and disease-modifying antirheumatic drugs (DMARDs). This evidence concerns the gene TNF and rheumatoid arthritis.