As for NRG1-ErbB4 pathway, downregulation of NRG1 expression could improve the activity of voltage-gated sodium channel and the excitability of ErbB4 positive intermediate neurons, then promoting the release of GABA, inhibiting the discharge of hippocampal pyramidal neurons, and interfering with the occurrence of epilepsy [30, 31]. This evidence concerns the gene NRG1 and epilepsy.