In addition, the downregulation of VEGF mediated by MSC-derived exosomes can affect the vascular behavior of endothelial cells in vitro; therefore, exosomal transfer of miR-100 may be a novel mechanism underlying the paracrine effects of MSC-derived exosomes and may provide a means by which these vesicles can modulate vascular responses within the microenvironment of cancer cells [50]. This evidence concerns the gene VEGFA and cancer.