Previous studies showed that (1) compared with normal prostate, PYCR1 was significantly upregulated in PCa at both mRNA and protein levels, (2) the expression levels of PYCR1 were significantly associated with Gleason scores, and 3) PYCR1 is involved in PCa cell proliferation and colony formation [58, 59]. Here, PYCR1 is linked to posterior cortical atrophy.