In conclusion, T-cell-associated cytokines/chemokines including IL-6, IL-1β, TNF-α, IL-4, IFN-γ, IL-5, IL-18, IL-2, IL-12p70, IL-13, IL-9, IL-17A, IL-23, IL-27, IL-10, IP-10, RANTES, MIP-1β, MCP-3, GRO-α, eotaxin, MIP-1α, MCP-1, MCP-3, and MIP-2 were all upregulated in the heart at day 7 and day 14 in the closed-chest murine MI/R model compared to the sham. Here, CCL5 is linked to myocardial infarction.