Compared with the control group, the ABCA1 C69T gene mutation significantly reduced the risk of hypertriglyceridemia in diabetic patients (dominant model: WMD = 0.66, 95% CI = 0.52–0.8, P < 0.0001, I2 = 60%; recessive model: WMD = 0.47, 95%CI = 0.11–0.83, P = 0.01, I2 = 32%). The gene discussed is ABCA1; the disease is hypertriglyceridemia.