Their results showed that two- to four-parameter combinations of the eight predictor/biomarker indices (MMSE, CDR-sb, CERAD-DR, HCV, Aβ42, Aβ42/40, T-tau and P-tau181) were numerically superior over the performance of a single biomarker index in predicting MCI subjects who progressed to AD. The gene discussed is MAPT; the disease is Alzheimer disease.