ORAI1 and breast cancer: Since ORAI1 expression decreased in lymph node metastatic tumors and high ORAI3 expression was a predictor of poor prognosis in both datasets, we investigated the possibility of a functional shift in the Ca2+ entry from SOCE (ORAI1-dependent) to Store-independent Ca2+ channel entry SICE (ORAI3-dependent) and its association with a poor outcome, as described in prostate and breast cancers [23,24].