Ferenci et al. demonstrated in a before-after study that 14 consecutive days of Legalon® SIL infusion combined with 7 days of Peg-IFN+RBV treatment dose-dependently and continuously decreased HCV viral load in chronic hepatitis C patients who were previously non-responders to the Peg-IFN+RBV therapy [39]. This evidence concerns the gene IFNA1 and chronic hepatitis C virus infection.