GBA1 and Parkinson disease: It seems that severe GBA mutations (as classified according to the subtype of GD that they are associated with), such as c.84dupG (84GG), c.115 + 1G >A (IVS2 + 1), c.1297G > T (V394L), c.1342G > C (D409H), c.1448T > C (L444P), and c.1263del + RecTL, are associated with a higher risk of causing PD compared to milder mutations, such as the N370S and c.84dupG (84GG) [45].