PKM and cancer: Finally, E-cadherin has also been associated with other metabolic players of cancer cells, such as PKM2, a key enzyme of the glycolytic pathway, where PKM2 silencing induced the upregulation of caspase 7, Bad and E-cadherin expression, as well as to a decrease of MMP (Matrix Metalloproteinase) 2 and 9, HIF1α, and VEGF, impairing cell migration and invasion, inhibiting proliferation, and inducing apoptosis and cell cycle arrest at the G0/G1 phase [85].