In vitro, they demonstrated that severe hypoxia induces the expression of FAT1 and that the depletion of endogenous FAT1 under hypoxia induces a decrease in HIF-1α, CAIX, GLUT1, VEGFA, MCT4, HK2, BNIP3, and REDD1, as well as a decrease in glioblastoma cell invasion [122]. The gene discussed is VEGFA; the disease is glioblastoma.