FGF2 and neoplasm: In the case of GBM, NDs have been observed to reduce the vascularization of GBM tumors grown on the chick embryo’s chorioallantoic membrane (CAM) by lowering the expression of the vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 FGF2 genes, and also to lower the tumor mass and volume [18,19].