TP53 and non-small cell lung carcinoma: However, in contrast to what was observed by Brunelli and co-workers [7] in A2780, NSCLC, H460 WT, and H460 S5 cells, we demonstrated that, in SH-SY5Y cells, moringin induced cell cycle arrest in the G2 phase, probably through the involvement of p53 and p21, as suggested by their upregulation which was induced by the moringin treatment at both the gene and protein levels.