PIKFYVE and autoimmune disease: Lastly, due to the important roles played by the PIP4K/PIP5K family of proteins in different cellular processes associated with a variety of pathological conditions (e.g., cancer, diabetes, chronic pain, autoimmune diseases) [66,67,68,69,70,71], the identified CSIs in these proteins, which are surface exposed and predicted to play important cellular functions, also provide potential means for development of novel therapeutics targeting specific diseases [72,73,74,75,76].