Furthermore, in view of my demonstration that F− exposure and loss of NKA plays a role in inflammatory lung diseases, this suggests that the significantly higher burden of childhood respiratory disorders documented in Australia, New Zealand, the Republic of Ireland (RoI) and North America compared to other developed peer countries without AFDW, as noted in large scale epidemiological studies [476,477,478,479], may be causally associated with chronic F− exposure in infancy and F−-induced inhibition of NKA. Here, TAC1 is linked to respiratory system disorder.