In addition, loss of NKA activity is also associated with rheumatoid arthritis [30,31], metabolic syndrome [32], including; chronic kidney disease [33,34,35]; diabetes mellitus [36,37]; diabetic nephropathy and cardiomyopathy [38,39,40]; cardiovascular complications [32,41,42,43]; hypertension [40,44,45,46,47,48,49,50,51,52] and obesity [11]. This evidence concerns the gene TAC1 and metabolic syndrome.