This elucidation may explain why NF-κB activation has been linked to many neurological disorders including autism [464,465,466,467], Alzheimer’s disease [468,469,470,471], Parkinson’s disease [472,473], as well as asthma, COPD, diabetes and cancer [474,475]. The gene discussed is NFKB1; the disease is early-onset autosomal dominant Alzheimer disease.