EIF4E and head and neck squamous cell carcinoma: The FaDu cell line has the highest ZFAS1 level among HNSCC cell lines, and our results suggest that ZFAS1 reduced the level of suppressor miR-150-5p and maintained a high level of EIF4E. It seems likely that the oncogenic EIF4E, in turn, up-regulates expression of some genes associated with EMT metastasis and could result in poor patient outcome (Figure 6).