Apart from adipokines, adipose tissue is also responsible for the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), which has been demonstrated to be elevated in NASH compared to simple steatosis, and IL-6, that may favor HCC development by inhibiting apoptosis and activating pro-oncogenic patterns [86,186]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.